Platform for in Vitro Toxicity Profiling

For life scientists wishing to profile samples for toxic effects, the Thermo Scientific Cellomics ToxInsight IVT Platform offers a complete solution to significantly enhance in vitro toxicology (IVT) assessment. Designed to simplify your workflow by multiplexing targets in each cell, ToxInsight™ can provide a clearer picture of potential toxic liabilities.  Traditional methods of assessing toxicity in vitro measure single targets in homogeneous formats and have a record of low predictive power.  ToxInsight leverages the proven power of automated cellular imaging to measure multiple toxicity indicators in each cell of the exposed population.  Combined cellular outputs are automatically compared to untreated populations producing a more sensitive, multi faceted risk assessment tool for in vitro toxicity testing.

Features

• A compact, and robust application focused cellular imaging reader for fully automated data capture and analysis
• Easy to use, operator centric software interface
• Automated image capture (4 colors) to collect multiple assay outputs per cell
• Reader optics matched to ToxInsight Cartridges offering appropriate reagents and analysis protocols for panels of targets
• Automated image analysis of biological responses evaluated against reference cell populations
• Intuitive summary reporting provides overall risk classification
• Additional plate QC reporting, dose response curve fitting, and visual (image) confirmation of biological results
• Uses 96/384 well plates, barcoding and automation friendly design
• Maintenance free, ultra-stable, solid state illumination with low power consumption
• Customer installable

Benefits

• Simplifies the workflow by eliminating the need for complex assay development and reagent validation/sourcing
• Superior sensitivity and specificity by combining novel assay endpoints including cell/organelle morphology and spatial distribution of intracellular targets
• Deeper insight into the mechanisms of toxicity by simultaneous assessment of multiple endpoints on a cell by cell basis
• Assay multiplexing reduces precious sample and cell usage costs
• Generation of multi-dimensional data increases the quality of decision making in your critical processes
• Low total cost of ownership with a “green design” that minimizes power usage and consumable