Home What is High Content Screening?

Definitions

Attention: open in a new window. PrintE-mail

 

 

cell (cell): 3b. the fundamental unit of all organisms and the physiochemical basis both of individual development and of organic evolution from the simplest protozoa to the most complex forms of plant and animal life.
cellomics (cell-o-mics):

1. the study of cells. What is in them, on them, around them, and between them. How they eat, sleep, grow, learn, react, and die. How they complete tasks and work as a team by signaling, influencing, stimulating, inhibiting and sometimes destroying each other.

2. The knowledge of cellular phenotype and function. A set of information about the relationships between all cellular components and how they work together in context, collected with a validated, automated “systems biology” approach

Cellomics, Inc. (cell): A company founded on the principles of cellomics, dedicated to providing all the tools required to generate and use cellular knowledge in the life sciences market. Now part of Thermo Fisher Scientific.
High Content Screening (HCS): (cell):

1. An integrated platform solution to make cellomics a tool for pharmaceutical and biopharmaceutical drug discovery. The platform includes: a) cell-based assay reagents and protocols to identify biology of interest, b) detection based on automated, multi-spectral fluorescence micro-imaging and software to extract, store and manage all data from images, and c) screen management, visualization, and analysis software to facilitate decisions in screening, lead optimization, and target validation.

2. A term used by drug discovery scientists to describe cell based assays that collect multiple pieces of useful information from each well of microplates. This data can be any combination of multiple targets, phenotypes, and cell subpopulation activities. In contrast to HCS, High Throughput Screening (HTS) typically makes only one measurement per well as a cell population average.